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LDN Research

Mar. 8, 2007

Posted by Jane Anderson under Uncategorized, Daily Journal

Institute of Experimental Neurology (INSPE) and Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy.

A sixth month phase II multicenter-pilot trial with a low dose of the opiate antagonist Naltrexone (LDN) has been carried out in 40 patients with primary progressive multiple sclerosis (PPMS). The primary end points were safety and tolerability. Secondary outcomes were efficacy on spasticity, pain, fatigue, depression, and quality of life. Clinical and biochemical evaluations were serially performed. Protein concentration of beta-endorphins (BE) and mRNA levels and allelic variants of the mu-opiod receptor gene (OPRM1) were analyzed. Five dropouts and two major adverse events occurred. The remaining adverse events did not interfere with daily living. Neurological disability progressed in only one patient. A significant reduction of spasticity was measured at the end of the trial. BE concentration increased during the trial, but no association was found between OPRM1 variants and improvement of spasticity. Our data clearly indicate that LDN is safe and well tolerated in patients with PPMS.

For more information on this study
Researchers: Gironi M, Martinelli-Boneschi F, Sacerdote P, Solaro C, Zaffaroni M, Cavarretta R, Moiola L, Bucello S, Radaelli M, Pilato V, Rodegher M, Cursi M, Franchi S, Martinelli V, Nemni R, Comi G, Martino G.

Dr. Burt Berkson, M.D., Ph.D.

Feb. 24, 2007

Posted by Jane Anderson under Samples
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Burt Berkson, M.D., Ph.D., has gotten amazing results in his medical practice treating various conditions (including cancer, MS, and terminal liver disease) with alpha lipoic acid and/or Low Dose Naltrexone. The site below features a transcript of an interview with Dr. Berkson in which he discusses some of his most notable cases:
http://tinyurl.com/berkson-on-ala-and-ldn
The site also reveals how incredibly difficult it has been for him to interest mainstream medicine in his discoveries.

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